| Matches by round |
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
| Match list: | By round By date Latest | Player stats: | Cards All players |
| R | Date | Home | Score | Away | HT | >2.5 | HT | FT | |
| 1 | 8/20/2017 | Sassuolo | 0 - 0 | Genoa | 0-0 | No | X | X | |
| 2 | 8/27/2017 | Torino | 3 - 0 | Sassuolo | 1-0 | Yes | 1 | 1 | |
| 3 | 9/10/2017 | Atalanta | 2 - 1 | Sassuolo | 1-1 | Yes | X | 1 | |
| 4 | 9/17/2017 | Sassuolo | 1 - 3 | Juventus | 0-1 | Yes | 2 | 2 | |
| 5 | 9/20/2017 | Cagliari | 0 - 1 | Sassuolo | 0-0 | No | X | 2 | |
| 6 | 9/24/2017 | Sassuolo | 0 - 1 | Bologna | 0-0 | No | X | 2 | |
| 7 | 10/1/2017 | Lazio | 6 - 1 | Sassuolo | 1-1 | Yes | X | 1 | |
| 8 | 10/15/2017 | Sassuolo | 0 - 0 | Chievo | 0-0 | No | X | X | |
| 9 | 10/22/2017 | SPAL | 0 - 1 | Sassuolo | 0-1 | No | 2 | 2 | |
| 10 | 10/25/2017 | Sassuolo | 0 - 1 | Udinese | 0-1 | No | 2 | 2 | |
| 11 | 10/29/2017 | Napoli | 3 - 1 | Sassuolo | 2-1 | Yes | 1 | 1 | |
| 12 | 11/5/2017 | Sassuolo | 0 - 2 | AC Milan | 0-1 | No | 2 | 2 | |
| 13 | 11/19/2017 | Benevento | 1 - 2 | Sassuolo | 0-0 | Yes | X | 2 | |
| 14 | 11/25/2017 | Sassuolo | 0 - 2 | Hellas Verona | 0-2 | No | 2 | 2 | |
| 15 | 12/3/2017 | Fiorentina | 3 - 0 | Sassuolo | 2-0 | Yes | 1 | 1 | |
| 16 | 12/10/2017 | Sassuolo | 2 - 1 | Crotone | 0-0 | Yes | X | 1 | |
| 17 | 12/17/2017 | Sampdoria | 0 - 1 | Sassuolo | 0-0 | No | X | 2 | |
| 18 | 12/23/2017 | Sassuolo | 1 - 0 | Inter Milan | 1-0 | No | 1 | 1 | |
| 19 | 12/30/2017 | AS Roma | 1 - 1 | Sassuolo | 1-0 | No | 1 | X | |
| 20 | 1/6/2018 | Genoa | 1 - 0 | Sassuolo | 0-0 | No | X | 1 | |
| 21 | 1/21/2018 | Sassuolo | 1 - 1 | Torino | 0-1 | No | 2 | X | |
| 22 | 1/27/2018 | Sassuolo | 0 - 3 | Atalanta | 0-1 | Yes | 2 | 2 | |
| 23 | 2/4/2018 | Juventus | 7 - 0 | Sassuolo | 4-0 | Yes | 1 | 1 | |
| 24 | 2/11/2018 | Sassuolo | 0 - 0 | Cagliari | 0-0 | No | X | X | |
| 25 | 2/18/2018 | Bologna | 2 - 1 | Sassuolo | 1-1 | Yes | X | 1 | |
| 26 | 2/25/2018 | Sassuolo | 0 - 3 | Lazio | 0-2 | Yes | 2 | 2 | |
| 28 | 3/11/2018 | Sassuolo | 1 - 1 | SPAL | 1-1 | No | X | X | |
| 29 | 3/17/2018 | Udinese | 1 - 2 | Sassuolo | 1-1 | Yes | X | 2 | |
| 30 | 3/31/2018 | Sassuolo | 1 - 1 | Napoli | 1-0 | No | 1 | X | |
| 27 | 4/3/2018 | Chievo | 1 - 1 | Sassuolo | 0-0 | No | X | X | |
| 31 | 4/8/2018 | AC Milan | 1 - 1 | Sassuolo | 0-0 | No | X | X | |
| 32 | 4/15/2018 | Sassuolo | 2 - 2 | Benevento | 1-1 | Yes | X | X | |
| 33 | 4/18/2018 | Hellas Verona | 0 - 1 | Sassuolo | 0-1 | No | 2 | 2 | |
| 34 | 4/21/2018 | Sassuolo | 1 - 0 | Fiorentina | 1-0 | No | 1 | 1 | |
| 35 | 4/29/2018 | Crotone | 4 - 1 | Sassuolo | 3-1 | Yes | 1 | 1 | |
| 36 | 5/6/2018 | Sassuolo | 1 - 0 | Sampdoria | 0-0 | No | X | 1 | |
| 37 | 5/12/2018 | Inter Milan | 1 - 2 | Sassuolo | 0-1 | Yes | 2 | 2 | |
| 38 | 5/20/2018 | Sassuolo | 0 - 1 | AS Roma | 0-1 | No | 2 | 2 |